Schools in Florida are shut down, along with restaurants, night clubs, Disney World, theaters, any public venue that isn’t essential. Field hospitals are being deployed around the state.
How did we get here?
In January I saw the news about an epidemic in Wuhan, China and wondered what the mainstream media thought about it. Not much as it turned out:
Worried About Catching The New Coronavirus? In The U.S., Flu Is A Bigger Threat1Allison Aubrey, National Public Radio, 29 Jan 2020.
Get a grippe, America. The flu is a much bigger threat than coronavirus, for now.2Lenny Bernstein, The Washington Post, 1 Feb 2020.
I had to visit amateur blogs and forums to find little gems like this:
A laboratory in Wuhan is on the cusp of being cleared to work with the world’s most dangerous pathogens.3David Cyranoski, Nature, 22 Feb 2017.
If the virus escaped, nobody could predict the trajectory.4Simon Wain-Hobson, virologist, Pasteur Institute, Nature, 12 Nov 2015.
Now, there’s a lot of nonsense on the web, but you can filter out the noise using fifth grade research techniques and concentrating on primary sources such as links to reputable medical or science journals.
The data backed by high-quality primary sources indicate this virus didn’t originate in a market:
- Wuhan, the center of the outbreak, has a Level 4 pathogen research lab, which is certified to work with aerosol-transmitted pathogens fatal to humans, for which there is no vaccine or treatment.3
- China has a history of pathogens escaping its labs. “The SARS virus has escaped from high-level containment facilities in Beijing multiple times, notes Richard Ebright, a molecular biologist at Rutgers University.” 3
- Although it’s very difficult for a virus to jump from an animal to a human without evolving first in an intermediate host, scientists at a US lab did it with a bat coronavirus.5 6 The Wuhan outbreak also involved a bat coronavirus.
- Two of the scientists who co-wrote the paper in item 3) work at the Wuhan lab:
- If you visit the Nature link at endnote 6 and click on Xing-Yi Ge, it states “Xing-Yi Ge. Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.”
- Similarly if you click on Zhengli-Li Shi, it states “Zhengli-Li Shi. Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.”
China has a history of pathogens escaping its labs. The center of the outbreak has a laboratory certified for working on pathogens fatal to humans. At least two of the doctors at that lab helped to get a bat coronavirus to jump from bats to humans without an intermediate host.
And if you want early warning of a pandemic so you can prep, you’ll get better information from a rocketry forum than The Washington Post or National Public Radio.
Update May 2021: Nicholas Wade wrote an article documenting the work at the Wuhan Institute of Virology, which was funded by the U.S. government.
Dr. Shi set out to create novel coronaviruses with the highest possible infectivity for human cells. Her plan was to take genes that coded for spike proteins possessing a variety of measured affinities for human cells, ranging from high to low. She would insert these spike genes one by one into the backbone of a number of viral genomes (“reverse genetics” and “infectious clone technology”), creating a series of chimeric viruses. These chimeric viruses would then be tested for their ability to attack human cell cultures (“in vitro”) and humanized mice (“in vivo”). And this information would help predict the likelihood of “spillover,” the jump of a coronavirus from bats to people.7Nicholas Wade, Bulletin of the Atomic Scientists, 5 May 2021.
Update June 2021: a 2017 science paper shows the Wuhan Institute of Virology was working on bat coronaviruses, courtesy of the U.S. taxpayer:
All sampling procedures were performed by veterinarians with approval from Animal Ethics Committee of the Wuhan Institute of Virology (WIVH05210201).
The ORF8 gene of SARS-CoV GZ02 and bat SARSr-CoV Rf1, and the ORF8a gene of SARS-CoV Tor2 were synthesized by Tsingke Biological Technology Co., Ltd (Wuhan, China).
We thank the Center for Instrumental Analysis and Metrology of Wuhan Institute of Virology, CAS, for the assistance in taking confocal microscope pictures (Dr. Ding Gao) and flow cytometry (Ms. Juan Min).
This work was jointly funded by…the National Institutes of Health (NIAID R01AI110964), the USAID Emerging Pandemic Threats (EPT) PREDICT program to PD and ZLS.8Hu, Ben, et al, PLOS Pathogens, 30 November 2017.
Update April 2022: Neanderthal DNA plays a big role in how badly COVID affects you. Neanderthals were a human species who went extinct 40,000 years ago. Europeans and Asians are descended from Neanderthals and 2% of their DNA comes from their Neanderthal ancestors. One Neanderthal gene found in 16% of Europeans and 50% of South Asians increases COVID hospitalizations by 60%.9 A different Neanderthal gene found in half of Europeans and Asians reduces COVD hospitalizations by 20%.10
Aubrey, Allison. Worried About Catching The New Coronavirus? In The U.S., Flu Is A Bigger Threat. National Public Radio. 29 Jan 2020. ↩
Bernstein, Lenny. Get a grippe, America. The flu is a much bigger threat than coronavirus, for now. The Washington Post. 1 Feb 2020. ↩
Cyranoski, David. Inside the Chinese lab poised to study world’s most dangerous pathogens. Nature, 23 Feb 2017. ↩↩↩
Butler, Declan. Engineered bat virus stirs debate over risky research. Nature, 12 Nov 2015. ↩
Menachery, V., Yount, B., Debbink, K. et al. A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence. Nature Medicine, 2015. ↩↩
Wade, Nicholas, The origin of COVID: Did people or nature open Pandora’s box at Wuhan?. Bulletin of the Atomic Scientists, 5 May 2021. ↩
Hu, Ben, et al. Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus. PLOS Pathogens, November 2017. ↩
Severe Covid-19 GWAS Group et al. Genomewide Association Study of Severe Covid-19 with Respiratory Failure. The New England Journal of Medicine, 15 October 2020. ↩
Zeberg, Hugo, and Svante Pääbo. A genomic region associated with protection against severe COVID-19 is inherited from Neandertals. Proceedings of the National Academy of Sciences of the United States of America, 02 March 2021. ↩